65521

+ The larger member in a sequence of primes formed by taking the product of the first n nonzero Fibonacci numbers and adding 1.

+ The largest prime less than 216. [Noe]

+ FactorInteger in Mathematica 5.0 performs trial division by primes up to 65521. [Terr]

(There is one curio for this number that has not yet been approved by an editor.)

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