Eric Clapton's most famous solo album was called 461 Ocean Boulevard. This was his comeback record after a long bout with heroin addiction. [Tignor]
The largest number for which ((10^2n)+1)/101 is known to be a prime number.
(461) is the (4 * 6 * 1)th prime. [Firoozbakht]
The Knoxville Convention Center contains a 461-seat lecture hall.
The largest 3-digit prime p such that 2p-p2 is prime. [Loungrides]
In Gore Verbinsky's cult movie "The Ring," Rachel Keller's licence number is IWR 461. [Olry]
The smallest prime number of verses in a Rhapsody of Homer’s Iliad, i.e., (3rd Rhapsody). The 461st verse, i.e., (the last verse of 3rd Rhapsody) is: «Ὣς ἔφατ᾽ Ἀτρεΐδης, ἐπὶ δ᾽ ᾔνεον ἄλλοι Ἀχαιοί.» [Loungrides]
The smallest prime that can be represented from the sum of two successive numbers that are both sphenic numbers, i.e., 230+231. [Loungrides]
(There are 2 curios for this number that have not yet been approved by an editor.)